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Home - Products - Cytoskeleton/Cell Adhesion Molecules - Glucokinase - Ro 28-1675

Ro 28-1675

CAS No. 300353-13-3

Ro 28-1675( Ro 028-1675 | RO 0281675 )

Catalog No. M13928 CAS No. 300353-13-3

A potent, allosteric activator of Glucokinase (GK) with SC1.5 of 0.24 uM.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Ro 28-1675
  • Note
    Research use only, not for human use.
  • Brief Description
    A potent, allosteric activator of Glucokinase (GK) with SC1.5 of 0.24 uM.
  • Description
    A potent, allosteric activator of Glucokinase (GK) with SC1.5 of 0.24 uM; augments both hepatic glucose metabolism and glucose-induced insulin secretion from isolated rodent pancreatic islets; lowers blood glucose levels and increases hepatic glucose uptake in rodent models of type 2 diabetes mellitus. Diabetes Preclinical.
  • In Vitro
    RO-28-1675 can reverse the inhibitory action of the human glucokinase regulatory protein (GKRP).
  • In Vivo
    RO-28-1675 (50 mg/kg; p.o.) reduces blood glucose levels in wild-type C57BL/6J mice.RO-28-1675 exhibits high oral bioavailability (mice 92.8%) and Cmax (1140 μg/mL) following oral administration (10 mg/kg). Animal Model:10 weeks old male C57BL/6J mice Dosage:50 mg/kg Administration:Oral administration Result:Reduced blood glucose levels.Animal Model:C57BL/6J mice Dosage:10 mg/kg (Pharmacokinetic Analysis Administration:Oral administration Result:Oral bioavailability (92.8%), Cmax (1140 μg/mL), T max (3.3 h).
  • Synonyms
    Ro 028-1675 | RO 0281675
  • Pathway
    Cytoskeleton/Cell Adhesion Molecules
  • Target
    Glucokinase
  • Recptor
    Glucokinase
  • Research Area
    Metabolic Disease
  • Indication
    Diabetes

Chemical Information

  • CAS Number
    300353-13-3
  • Formula Weight
    378.5089
  • Molecular Formula
    C18H22N2O3S2
  • Purity
    >98% (HPLC)
  • Solubility
    10 mM in DMSO
  • SMILES
    O=C(NC1=NC=CS1)[C@@H](C2=CC=C(S(=O)(C)=O)C=C2)CC3CCCC3
  • Chemical Name
    Benzeneacetamide, α-(cyclopentylmethyl)-4-(methylsulfonyl)-N-2-thiazolyl-, (αR)-

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Grimsby J, et al. Science. 2003 Jul 18;301(5631):370-3. 2. Haynes NE, et al. J Med Chem. 2010 May 13;53(9):3618-25. 3. McKerrecher D, Bioorg Med Chem Lett. 2005 Apr 15;15(8):2103-6.et al. 4. Assefa Z, et al. PLoS One. 2014 Jan 9;9(1):e85174.
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